Dendritic Cell-Mediated Allogeneic T Cell T Cell Proliferation and Is Required for LIGHT, a TNF-Like Molecule, Costimulates
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LIGHT is a recently identified member of the TNF superfamily that is up-regulated upon activation of T cells. Herpesvirus entry mediator, one of its receptors, is constitutively expressed on immature dendritic cells (DCs). In this report, we demonstrate that LIGHT induces partial DC maturation as demonstrated by Ag presentation and up-regulation of adhesion and costimulatory molecules. LIGHT-st...
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